Sister Chromatid Cohesion

Sister chromatid cohesion.

During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation. Cohesion is mediated by cohesin complexes that are thought to embrace sister ch...

Sister Chromatid Cohesion and Aneuploidy

Establishment of Sister Chromatid Cohesion

The process of sister chromatid pairing, or cohesion establishment, is coupled to DNA replication and fundamental to proper chromosome segregation and cell viability. In the past year, several articles have provided important new insights into cohesion establishment, an activity predicated on the acetyltransferase Ctf7/Eco1. Here, I review new findings that the conversion of chromatid-bound coh...

Targeted Sister Chromatid Cohesion by Sir2

The protein complex known as cohesin binds pericentric regions and other sites of eukaryotic genomes to mediate cohesion of sister chromatids. In budding yeast Saccharomyces cerevisiae, cohesin also binds silent chromatin, a repressive chromatin structure that functionally resembles heterochromatin of higher eukaryotes. We developed a protein-targeting assay to investigate the mechanistic basis...

Holding your own: establishing sister chromatid cohesion.

Chromosome Segregation and Genome Integrity At cell division, both daughter cells receive only one copy of the parental genome. Not surprisingly, chromatin plays a role at numerous stages to ensure that genome segregation occurs with high fidelity. First, each chromosome is duplicated to produce two identical chromosomes called sister chromatids. Second, sister chromatids become paired, or glue...